The primary endpoint is not IQ but irritability and socialization. Still this shows the benefit of studying genes and intelligence and I predict that the lessons for Arbaclofen will turn out to be more useful than the lessons from the Abecedarian or some other early childhood intervention study.Arbaclofen is different because it was developed by scientists studying the fundamental genetic problems in Fragile X. Arbaclofen is designed to help restore the balance of neurotransmitters, chemical messengers in the brain that communicate between cells."It's not a shot in the dark,"Schultz says. "It's a very rational treatment based on understanding the biology of Fragile X.
Wednesday, September 19, 2012
Fragile X in the news
Seaside therapeutics GABA-B receptor agonist just had a positive phase II trial results:
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5 comments:
Hey statsquatch you know what happened to Chuck's blog? It's gone private, I requested for accessbut no response yet. Do you have access? Where am I gonna get my race and IQ fix now!
No idea ambiguous. Maybe he saw some data that put him over the edge.
The last I saw was that he'd found something that did not look good for the strong hereditarian hypothesis regarding the B-W gap, something regarding the UK I think. I asked him about it a few days before he hid his blog but no response.
Indeed, that's a great loss. Fortunately, I still managed to "print" two of his blog posts. See here :
Magnitude of the B-W IQ gap projected to 2008
Misunderstanding heritability
But I'm still mad. His blog contains a lot of good stuff. Also, I'm currently writing on something big about the race and IQ debate, and I would like to know what he thinks about that. Well, this does not matter now. I suppose.
By the way, Statsquatch, Rowe in the below paper said
http://menghusblog.files.wordpress.com/2012/09/under-the-skin-on-the-impartial-treatment-of-genetic-and-environmental-hypotheses-of-racial-differences.pdf
"A survey study, for example, could be used to test an environmental hypothesis that racial discrimination causes IQ variation in Blacks. Among the variables that could be used would be (a) skin color, as a proxy for social reactions to the individual; (b) perceived discrimination, as a direct assessment of social reactions; and (c) individual genetic admixture. A genetic hypothesis would predict that individual admixture will give the best prediction of IQ, controlling for skin color and perceived discrimination. To the contrary, an environmental hypothesis would predict a dominant effect of perceived discrimination. With such variables, researchers with different positions on the racial difference question could come together to design a single, large-scale survey to test their hypotheses about racial differences."
I'm very interested to know whether some researchers have investigated the issue. Are you aware of this ?
He might back. This sort of blogging can be stressful. I was offline for a year.
Meng,
I have never seen that exact study. The closest think I know of is the study I blogged:
http://statsquatch.blogspot.com/2012/09/mald-function.html
The data for Rowe's study may actually exist somewhere. I bet there is a data base with IQ and enough DNA to estimate admixture and skin color.
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